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. 2000 Sep 18;150(6):1361–1374. doi: 10.1083/jcb.150.6.1361

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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DaPKC is required for localization of Baz and Insc and for correct orientation of the metaphase plate in neuroblasts. Hemizygous DaPKC^k06403 embryos derived from C(2)v mothers were stained for Baz and DNA (a and b) or for Insc and DNA (c and d). Baz staining is strongly reduced and is not localized to the apical cortex in metaphase neuroblasts of DaPKC^k06403 hemizygous embryos (a and b), while Insc is still detectable in the cytoplasm but fails to form a tight apical crescent (c and d). Note also that orientation of metaphase plates with respect to the surface of the embryo is abnormal in DaPKC^k06403 mutants (b and d). Neuroblasts are marked by asterisks. Apical is up in all panels. b and d are merged images of the Baz and DNA channels (b) or the Insc and DNA channels (d). Bar = 10 μm.