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. 2000 Sep 18;150(6):1283–1298. doi: 10.1083/jcb.150.6.1283

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© 2000 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Ultrastructural observations of mitochondrial alterations in cardiac muscle. (A) Wild type (+/+) cardiac muscle showing normal cardiomyocyte ultrastructural appearance with laterally aligned myofibrils and strands of mitochondria (arrow) between the myofibrils. (B) Desmin-null (−/−) cardiac muscle demonstrating proliferation and swelling of mitochondria (arrow) between myofibrils and subsarcolemmal clumping of mitochondria (m). (C) Desmin-null cardiac muscle from exercised mice exhibiting severe mitochondrial swelling, including mitochondria with broken cristae (arrow). An area of severe mitochondrial proliferation is also observed (p). (D) Desmin-null cardiac muscle showing severe architectural disruption, large empty spaces surrounded by mitochondria, and mitochondria sequestered within a membrane-limited structure (arrowhead). (E) High magnification view of area in D (asterisk) showing mitochondria enclosed in a membrane-limited structure (arrowhead) within a myocyte. Note the mitochondria display normal condensed morphology. Bars: (A–D) 5 μm; (E) 1 μm.

Ultrastructural observations of mitochondrial alterations in cardiac muscle. (A) Wild type (+/+) cardiac muscle showing normal cardiomyocyte ultrastructural appearance with laterally aligned myofibrils and strands of mitochondria (arrow) between the myofibrils. (B) Desmin-null (−/−) cardiac muscle demonstrating proliferation and swelling of mitochondria (arrow) between myofibrils and subsarcolemmal clumping of mitochondria (m). (C) Desmin-null cardiac muscle from exercised mice exhibiting severe mitochondrial swelling, including mitochondria with broken cristae (arrow). An area of severe mitochondrial proliferation is also observed (p). (D) Desmin-null cardiac muscle showing severe architectural disruption, large empty spaces surrounded by mitochondria, and mitochondria sequestered within a membrane-limited structure (arrowhead). (E) High magnification view of area in D (asterisk) showing mitochondria enclosed in a membrane-limited structure (arrowhead) within a myocyte. Note the mitochondria display normal condensed morphology. Bars: (A–D) 5 μm; (E) 1 μm.