Figure 3.

Identification of α_vβ₅ in the developing human pancreas. Confocal immune fluorescence on cryostat sections stained for α_vβ₅ (A, green), insulin (C, red), and glucagon (B, blue). The three fluorophore spectra are merged in D. Bright levels of α_vβ₅-specific immune reactivity are detected in pancreatic ducts (asterisk), whereas significantly lower levels characterize endocrine cells organized in larger islet-like clusters. However, single endocrine cells adjacent to, or emerging from, the ductal epithelium retain significant higher levels of α_vβ₅ expression (D; arrowheads). Bar, 100 μm.