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. 2001 Jun 25;153(7):1403–1414. doi: 10.1083/jcb.153.7.1403

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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FE65 enhances the ability of APP to increase the rate of wound healing. Confluent monolayers of MDCK cells overexpressing APP (+APP/−FE65; a, c, e, and g) or both APP and FE65 (+APP/+FE65, b, d, f, and h) were grown on grids then wounded with a pipette tip. The wounds were photographed immediately after wounding (a and b). The same points on the grids were again photographed 9 (c and d), 12 (not shown), 15 (e and f), 18 (not shown), and 21 h (g and h) after wounding. (i) The distance the wound edges had traveled was determined at the same three points on each of six wounds. The data represent means ± SE. *P < 0.05, **P < 0.001, and **P < 0.0001 by ANOVA. Similar results were seen with two additional FE65 overexpressing clones.