Table 1.
Wound Closure after 1 d
| Fully closed | Partially closed | Fully open | Totals | |
|---|---|---|---|---|
| −APP/−FE65 | 0 | 0 | 25 | 25 |
| −APP/+FE65 | 4 | 6 | 10 | 20 |
| +APP/−FE65 | 4 | 17 | 2 | 23 |
| +APP/+FE65 | 52 | 5 | 0 | 57 |
| Totals | 60 | 28 | 37 | 125 |
Confluent monolayers of wild-type MDCK cells (−APP/−FE65), MDCK cells stably overexpressing APP (+APP/−FE65) or FE65 (−APP/+FE65), and MDCK cells stably overexpressing both APP and FE65 (+APP/+FE65), grown on grids, were wounded with a pipette tip. The wounds were allowed to heal for 1 d and then examined at grid intersections and scored as fully closed, partially closed, or fully open.