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. 2001 Jul 23;154(2):435–446. doi: 10.1083/jcb.200105003

Figure 1.

Figure 1.

Domain structures of a- and b-neurexins (top) and locations of Ig and GST fusion proteins used for binding studies (bottom). Principal features of neurexins are indicated on top: SP, signal peptide; LNS, LNS domains, named after laminin G-domain repeats, neurexins, and sex hormone–binding globulin, and also referred to as LG domains; EGF, EGF-like sequences; CHO, carbohydrate attachment site; T, transmembrane region; numbered arrows, positions of canonical alternative splice sites (Ullrich et al., 1995). The regions of neurexins included in the various Ig and GST fusion proteins are displayed below the neurexin diagram; these proteins are named after the neurexin from which they were derived, followed by a unique identifying number. The splice site inserts contained in the fusion proteins are indicated above the lines. A single variant for splice site no. 1 (which is not in an LNS domain) was analysed (+, B-variant; Ullrich et al., 1995) and three variants for splice site no. 2 in which “−” corresponds to the no-insert variant, “+” to the small insert (sequence in neurexin 1α: HSGIgHAM), and “++” to the large insert (sequence in neurexin 1α: HSGIgHAMVNKLHCS). Two variants were studied for splice site nos. 3 and 4 (“+,” 3 residue insert for splice site no 3 and 30 residues for splice site no. 4; “−,” no insert).