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Sarcolemmal expression of nNOS and aquaporin-4 in genetic crosses of α-syntrophin–null mice with transgenic mice. Both nNOS and aquaporin-4 are absent from the sarcolemma of α-syntrophin–null mice. Muscle from α-syntrophin–null mice crossed with Tg α-Syn mice shows sarcolemmal expression of both nNOS and aquaporin-4. Sarcolemmal expression of these proteins is not restored in muscle of α-syntrophin–null mice crossed with Tg ΔPDZ mice. Bar, 50 μm.
