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. 2001 Oct 1;155(1):133–144. doi: 10.1083/jcb.200106148

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Copyright © 2001, The Rockefeller University Press

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Figure 8. — (A) Entry levels of the different strains of N. meningitidis in HBMECs. HBMECs were infected with the wild-type (WT), the PilT-defective mutant (PilT⁻), or the PilE-defective mutant (PilE⁻) of the 2C43 strain of N. meningitidis. After 4 h, the number of internalized bacteria in relation to the number of adherent bacteria was determined. (B) Effects of PP2, AG1478, AG1296, and Y27632 on N. meningitidis entry in HBMECs. Cells were either left untreated (NT) or pretreated for 2 h with 5 μM PP2, 5 μM AG1478, 5 μM AG1296, 30 μM Y27632, or with both inhibitors PP2+AG1478 or PP2+Y27632, as indicated. Cells were infected with the wild-type strain of N. meningitidis for 4 h in the presence of the inhibitors. The percentage of internalized bacteria in relation to the entry or adhesion of the wild-type strain in absence of any activator or inhibitor was determined, and average values (±SEM) from four independent experiments are presented.