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. 2001 Sep 17;154(6):1125–1134. doi: 10.1083/jcb.200106011

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Copyright © 2001, The Rockefeller University Press

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Figure 8. — Two models for the spindle. (a) Eg5 (green). Other motor proteins, including dynein/dynactin (blue), that interact with a static matrix (black) and microtubules (red) that are fluxing polewards (arrows). The nonmicrotubule mechanical ensemble may be an organized structure (black), whose assembly and maintenance can depend on spindle microtubules, or it may be an aspect of spindle cytoarchitecture. (b) A model for the spindle where motors, including Eg5, interact with microtubules alone. These motors crosslink and generate forces against microtubules that flux polewards.