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. 2001 Oct 29;155(3):447–458. doi: 10.1083/jcb.200105017

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Copyright © 2001, The Rockefeller University Press

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Figure 9. — Relationship between α6β4 signaling and assembly of hemidesmosomes. Hypothetical model of the underlying pathways. We have observed that the palmitoylated fraction of α6β4 is localized in lipid rafts and is preferentially associated with Fyn and Yes (unpublished data). We hypothesize that this fraction of α6β4 mediates recruitment of Shc and activation of Ras and PI-3K. The EGF-R induces α6β4 signaling by activating Fyn and Yes and causing phosphorylation of the β4 cytoplasmic domain. It is likely that the signaling fraction of α6β4 exists in dynamic equilibrium with the cytoskeletal fraction involved in assembly of hemidesmosomes. We hypothesize that assembly of hemidesmosomes requires dephosphorylation of the β4 tail (Dans et al., 2001).