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. 2007 Dec 24;204(13):3067–3076. doi: 10.1084/jem.20071416

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Copyright © 2007, The Rockefeller University Press

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Figure 1. — Increased colonic inflammation in JAM-A^−/− mice. (A) Increased small lymphoid aggregates in JAM-A^−/− mice. (B) Large lymphoid aggregates in JAM-A^−/− mice identified as isolated lymphoid follicles. (C) Large, isolated submucosal lymphoid follicles observed only in JAM-A^−/− mice. CD11c staining is shown in red. (D) Increased PMN in the colonic mucosa of JAM-A^−/− mice. Bars, 40 μm. (E) MPO activity in the colonic mucosa of JAM-A^−/− mice and littermate controls (n = 6). Horizontal bars represent the mean.