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. 2007 Dec 24;204(13):3195–3208. doi: 10.1084/jem.20071224

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Copyright © 2007, The Rockefeller University Press

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Figure 4. — V_H cRS cleavage is dependent on Rag1. (A) BM B cells with a pro–B phenotype (B220^loCD43⁺IgM⁻Lin⁻) and a pre–B phenotype (B220^loCD43⁻IgM⁻Lin⁻) were sorted from sibling H50G^+/−Rag1^+/− (middle) or H50G^+/−Rag1^−/− (right) mice. Resolution of pro- and pre–B cells in H50G transgenic mice was not as complete as in RAG2:GFP mice (Fig. 3 A). Mature and immature B cells (+IgM) were excluded when anti-IgM was used as a negative marker (-IgM). (B) LM-PCR demonstrated SEs at both physiological RSs (J_H2, Jκ2) and cRSs (J558) were present only in RAG1/2-sufficient cells.