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. 2007 Dec 24;204(13):3103–3111. doi: 10.1084/jem.20071800

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Copyright © 2007, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 2. — Reduced survival and perinatal hemorrhage in Tln1^fl/fl Cre⁺ mice. (A) Tln1 ^fl/fl Cre⁺ mice have prolonged bleeding times in a tail bleeding assay. Time to cessation of bleeding after tail resection was recorded for up to 10 min, at which time bleeding was stopped by cauterization. (B) Example of 1-d-old Tln1 ^fl/fl Cre⁺ pup found dead with visible internal hemorrhage (arrows). Table showing reduced survival of Tln1 ^fl/fl Cre⁺ mice. The number of animals obtained from Tln1 ^fl/fl Cre² × Tln1 ^fl/fl Cre⁺ breeding at 3 wk of age is shown. (C) Incidence of fecal blood in Tln1 ^fl/fl Cre⁺ and Tln1 ^fl/fl Cre² mice at 8–10 wk of age was determined by a guaiac-based hemoccult assay. (D) Peripheral red blood cell counts from 10-wk-old Tln1 ^fl/fl Cre⁺ and Tln1 ^fl/fl Cre² littermates.