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The D5 bulge cross-links to catalytically important residues. Mapping of D5 cross-links by reverse transcription primer extension. Cross-links are indicated by asterisks (*). (A) Nucleotide 838 in the D5 bulge cross-links to G5 near the 5′ splice site. (B) Nucleotide 839 in the D5 bulge cross-links to G588 in J2/3 linker region.
