FIGURE 7.

Proposed model for 3′ BTE-mediated recruitment of translational machinery to viral mRNA. For simplicity, only the factors relevant to this report are shown. eIF4F (4G + 4E) binds the BTE structure in the 3′ UTR. The BTE and eIF4E bind eIF4G directly, while eIF4E and unidentified pulled-down proteins (indicated by question mark) may or may not bind the BTE directly. Long-distance base-pairing (parallel lines connecting a stem–loop in the BTE with the stem–loop adjacent to the AUG) juxtaposes the BTE-bound factors near the 5′ end. This delivers eIF4F and possibly other factors to the 43S ribosomal complex at the 5′ end (dashed arrow). eIF4G and possibly other factors interact with the ribosome to facilitate ribosomal scanning (horizontal arrow). See text for details. Reproduced with permission from Miller et al. (2007); ©2007 the Biochemical Society.