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. 2007 Dec 21;3(12):e232. doi: 10.1371/journal.pgen.0030232

Figure 7. Expression of Apoptotic-Related Genes in HoxD Mutant Kidneys.

Figure 7

(A) qPCR measurements of the indicated genes were performed in newborn kidneys from WT, Del(10–11), Del(10–13), Del(4–11) and Del(4–13) strains. Values represent the mean of three independent experiments, after normalization to the WT. Independent Student's t test (HoxD deletions versus WT): *, P < 0.05; **, P < 0.01.

(B) An increased expression of Gdf5 in the epithelial tubules of Del(4–11) and Del(4–13) newborn kidneys was observed both at the mRNA and protein levels (top). C-MYC and phospho-SMADs (bottom) were also up-regulated in renal tubules. Tubules are shown at higher magnification in the insets. Cell nuclei were counterstained with DAPI (blue).