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. 1999 Nov 1;147(3):599–610. doi: 10.1083/jcb.147.3.599

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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In vivo effects of BM-DC–derived exosomes. Immunocompetent (A) or nude (B) mice bearing 4-d-old TS/A mammary tumors were injected intradermally with exosomes (5 μg/mouse) produced by BM-DCs pulsed with AEP (i.e., MHC-associated peptides) from either TS/A tumor cells (DC ex-TS/A AEP) or splenic cells (DC ex-Spleen AEP). Tumor size was monitored weekly. Tumor growth was significantly delayed in tumor-AEP exosome–injected mice, compared with splenic-AEP exosome– or saline-injected mice (A). In nude mice lacking T lymphocytes, TS/A tumor growth was not affected by the same treatments (B). Each experimental group included five mice. Experiments were reproduced twice with similar results. Asterisks represent significant results at 95% using Fisher's exact method compared with injection of saline.