Table 2.
Clinical response evaluation of patients on the randomized trial
No. patients (response duration in months)* |
||||
---|---|---|---|---|
Arm 1 | Arm 2 | Arm 3 | Arm 4† | |
Randomized | 13 | 14 | 20 | NA |
Evaluable | 13 | 13 | 19 | 17 |
CR | 0 | 0 | 0 | 0 |
PR | 0 | 0 | 2 (4, 8) | 5 (3, 4, 9,18, 40+) |
MR | 0 | 0 | 0 | 0 |
MXR | 1 | 2 | 6 | 3 |
SD | 1 (6) | 1 (4) | 1 (4) | 1 (5) |
PD | 11 | 10 | 10 | 8 |
Abbreviations: NA, not applicable; CR, complete response; PR, partial response; MR, minor response; MXR, mixed response; SD, stable disease; PD, progressive disease.
Duration of stable disease was measured from initiation of treatment. Duration of response was measured from date of achieving response.
In nonrandomized Arm 4, select patients from Arms 1 and 2 with progressive disease subsequently received high-dose IL-2 as single-agent therapy.