Table 5.
Melanoma-associated antigen expression in 12 new metastatic lesions appearing during therapy in eight patients on the randomized trial
| Arm (patient) | Biopsy site | Biopsy process* | % Positive tumor cells
|
||
|---|---|---|---|---|---|
| Tyrosinase | gp100 | MART-1 | |||
| 1 (3) | Brain | FS | 0 | <25 | <25 |
| 1 (6) | Bone | FS | >75 | >75 | >75 |
| 1 (9) | Brain | FS | >75 | ND | ND |
| 1 (10) | S.c. | CB | >75 | 0 | 50–75 |
| S.c. | CB | 50–75 | <25 | <25 | |
| 2 (15) | Lymph node | CB | >75 | 50–75 | >75 |
| 2 (20) | Lymph node | FS | <25 | 25–50 | 50–75 |
| S.c. | FS | <25 | 50–75 | 50–75 | |
| S.c. | FS | <25 | 0 | 0 | |
| 3 (29) | S.c. | CB | >75 | >75 | <25 |
| S.c. | CB | >75 | >75 | 0 | |
| 3 (43) | S.c. | CB | >75 | >75 | >75 |
*
FS, frozen section of excised specimen; CB, paraffin-embedded cell block of fine-needle aspiration specimen.