Table 4.
Mean PAH-DNA adduct levels in prostate tumor and adjacent nontumor prostate cells among all study subject and within major ethnic group for genotype combinations of PAH metabolism and conjugation genes
| Genotype combination | All subjects
|
Caucasians
|
African Americans
|
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Tumor
|
Nontumor
|
n | Tumor
|
Nontumor
|
n | Tumor
|
Nontumor
|
|||||||
| Mean ± SE | P | Mean ± SE | P | Mean ± SE | P | Mean ± SE | P | Mean ± SE | P | Mean ± SE | P | ||||
| CYP1B1 Leu432Val and GSTP1 Ile105Val: | |||||||||||||||
| Lower metabolism and higher conjugation:* CYP1B1 Leu/Leu or Leu/Val and GSTP1 Ile/Val or Val/Val | 159 | 0.1679 ± 0.0047 |
— | 0.2179 ± 0.0065 |
— | 96 | 0.1688 ± 0.0063 |
— | 0.1980 ± 0.0408 |
— | 57 | 0.1695 ± 0.0080 |
— | 0.2275 ± 0.0112 |
— |
| Faster metabolism and lower conjugation:* CYP1B1 Val/Val and GSTP1 Ile/Ile | 52 | 0.1570 ± 0.0083 |
0.26 | 0.2218 ± 0.0115 |
0.77 | 22 | 0.1589 ± 0.0134 |
0.51 | 0.2474 ± 0.0078 |
0.66 | 29 | 0.1560 ± 0.0111 |
0.33 | 0.2187 ± 0.0155 |
0.64 |
| mEH His139Arg and GSTP1 Ile105Val: | |||||||||||||||
| Lower metabolism and higher conjugation:* mEH Arg/Arg and GSTP1 Ile/Val or Val/Val | 31 | 0.1537 ± 0.0108 |
— | 0.2316 ± 0.0080 |
— | 16 | 0.1332 ± 0.0135 |
— | 0.1754 ± 0.0222 |
— | 15 | 0.1626 ± 0.0105 |
— | 0.2107 ± 0.1338 |
— |
| Faster metabolism and lower conjugation:* mEH His/His or His/Arg and GSTP1 Ile/Ile | 126 | 0.1630 ± 0.0053 |
0.08 | 0.2150 ± 0.0162 |
0.36 | 81 | 0.1651 ± 0.0061 |
0.04 | 0.2451 ± 0.0100 |
0.005 | 42 | 0.1771 ± 0.0182 |
0.49 | 0.2603 ± 0.0238 |
0.08 |
| CYP1B1 Leu432Val and mEH His139Arg and GSTP1 Ile105Val: | |||||||||||||||
| Lower metabolism and higher conjugation:* mEH Arg/Arg and CYP1B1 Leu/Leu or Leu/Val & GSTP1 Ile/Val or Val/Val | 18 | 0.1497 ± 0.0166 |
— | 0.2256 ± 0.0198 |
— | 18 | 0.1354 ± 0.0133 |
— | 0.1920 ± 0.0157 |
— | 6 | 0.1840 ± 0.0321 |
— | 0.3060 ± 0.0408 |
— |
| Faster metabolism and lower conjugation:* mEH His/His or His/Arg and CYP1B1 Val/Val & GSTP1 Ile/Ile | 46 | 0.1587 ± 0.0102 |
0.65 | 0.2236 ± 0.0122 |
0.93 | 18 | 0.1658 ± 0.0111 |
0.10 | 0.2363 ± 0.0132 |
0.05 | 27 | 0.1547 ± 0.0138 |
0.41 | 0.2121 ± 0.0175 |
0.05 |
NOTE: All analyses were adjusted for age, smoking, alcohol, Gleason score, tumor stage, and PSA at diagnosis. Analyses in the total sample were also adjusted for ethnicity.
*
Putative metabolism and conjugation combinations (see text for details).