Figure 2.
Hyperpolarization of RMP and shortening of the APD induced by external HCO3− A, time course of the average changes in RMP after switching the superfusate from Hepes- to HCO3−-buffered solution (n = 9). B, time course of the percentage average changes (with respect to the value in Hepes measured immediately before the switch to HCO3−) in APD50 and APD90 induced by external HCO3− (n = 9). External HCO3− induced a slight RMP hypepolarization and a significant and relevant shortening of the APD.