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APD shortening induced by 5 mm HCO3− Average values of APD50 and APD90 in Hepes and after 8–10 min with 5 mm HCO3− in the extracellular solution (n = 9). This concentration of HCO3− induced an APD50 and APD90 shortening of 19.3 ± 4.6% and 11.9 ± 3.8% (n = 9) of the values in the absence of HCO3−, respectively. *Significantly different from Hepes.
