Figure 7.

Blockers of 5-HT_2a receptors inhibit sensory discharge induced by low glucose in cocultured neurones A, sample traces showing reversible inhibition of low glucose-induced (0.1 mm gluc/P_O2 ≈ 140 mmHg) sensory discharge by 10 nm ritanserin. Similar results were obtained during application of ‘physiological hypoglycaemia’ (3.3 mm gluc/P_O2 ≈ 90 mmHg) in the presence of 50 μm ketanserin (ket; B) and 40 nm ritanserin (rit; C). Effects of ritanserin on low glucose-induced spike frequency (F) discharge are plotted as a ratio F_rit/F_control for groups of cocultured petrosal neurones as indicated in the bar graph (D); F_control and F_rit refer to the spike frequency before and during ritanserin, respectively. Note ratio is < 1, due to inhibition of the discharge by ritanserin.