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. 2006 Nov 23;578(Pt 3):735–750. doi: 10.1113/jphysiol.2006.121871

Figure 8.

Figure 8

Blockers of GABAB receptors potentiate sensory discharge induced by low glucose in cocultured neurones A, sample traces showing reversible potentiation of low glucose-induced (0.1 mm gluc/PO2 ≈ 140 mmHg) sensory discharge by 0.1 μm CGP 55845, a GABAB receptor blocker. A similar potentiation was obtained during application of ‘physiological hypoglycaemia’ (3.3 mm gluc/PO2 ≈ 90 mmHg) as exemplified in B. Effects of CGP 55845 on low glucose-induced spike frequency (F) discharge are plotted as a ratio FCGP/Fcontrol for groups of cocultured petrosal neurones as indicated in the bar graph (C); Fcontrol and FCGP refer to the spike frequency before and during CGP 55845, respectively. Note ratio is > 1, due to potentiation of the discharge by CGP 55845.