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Multistep resistance selection with imipenem from two clinical strains of A. baumannii
| A. baumannii strain | Initial MICa before exposure to drug
|
MICa of resistant mutants (fold reduction)
|
||||
|---|---|---|---|---|---|---|
| IMP | MEM | IMP | IMP + CCCPb | MEM | MEM + CCCPc | |
| ab8 | 1 | 0.5 | 256 | 64 (4) | 8 | 4 (2) |
| ab1254 | 3 | 0.75 | 128 | 16 (8) | 6 | 3 (2) |
Determination of MIC using the broth dilution method. IMP, imipenem; MEM, meropenem.
The concentration of CCCP is 24 μg/ml.
The concentration of CCCP is 2 μg/ml.
