TABLE 2.

Effects of different cyclic tetrapyrrole treatments on scrapie strain 263K incubation periods in Tg7 mice

Compound	Dose	Dosing regimena	Scrapie infection route	Incubation periods (days)	Mean ± SD
None	None		i.p.	85, 76, 93, 91, 83, 83, 85, 97	86.6 ± 6.7
Cu(II)PcS4	25 mg/kg, i.p.	M, W, F for 6 wk starting 2 wk prior to inoculation	i.p.	335, 354, 353, 365, 396, 294, 378, 332	350.9 ± 31.2
Cu(II)PcS4	25 mg/kg, i.p.	M, W, F until death starting 50 days after inoculation	i.p.	98, 97, 83, 91, 87, 83, 87, 82, 83	87.9 ± 6.2
Noneb	50 μl PBS, i.c.	Days 14, 21, 28, 35, 42	i.c.	42, 42, 44, 44, 45, 45, 46, 46, 46, 47, 47, 48, 51, 52, 53	46.5 ± 3.3
Cu(II)PcS4	50 μl 0.5 mg/ml, i.c.	M, W, F for 3 wk starting 2 wk after inoculationc	i.c.	51, 42, 51, 58, 79, 48, 45, 48	52.8 ± 11.6
Cu(II)PcS4	50 μl 0.5 mg/ml, i.c.	Days 14, 21, 28, 35, 42	i.c.	41, 47, 46, 47, 44, 47, 45, 45	45.3 ± 2.1
Fe(III)TSPb	50 μl 0.5 mM, i.c.	Days 14, 21, 28, 35, 42	i.c.	53, 54, 58, 59, 59, 61, 62, 63, 63, 64, 65, 65, 71	61.3 ± 4.8
Mn(III)TSP	50 μl 0.5 mM, i.c.	Days 14, 21, 28, 35, 42	i.c.	46, 47, 48, 48, 48, 49, 50, 51	48.4 ± 1.6

^aM, Monday; W, Wednesday; F, Friday.

^bCombined data from two separate but identically conducted experiments.

^cTreatments were stopped at 3 weeks due to observed toxicity.