TABLE 1.
Demographic and clinical characteristics of patientsa
| Patient and sample set | Sex | Age (yr) | AMB LF | Cumulative dose (mg) | Interval (h) | Result for plasma sample
|
Result for pleural effusion sample
|
Diagnosis or condition(s) | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Crea concn (mg/dl) | Protein concn (g/dl) | LDH concn (U/liter) | Protein concn (g/dl) | LDH concn (U/liter) | No. of RBC | No. of cells/μl | |||||||
| 1 | M | 76 | LAMB | Sepsis, pneumonia, pancytopenia | |||||||||
| Sample set A | 1,050 | 22.5 | 0.60 | 5.73 | 425 | 2.57 | 281 | ++ | 700 | ||||
| Sample set B | 1,650 | 4 | 0.40 | 5.53 | 417 | 2.12 | NA | + | NA | ||||
| 2 | M | 66 | ABCD | 150 | 14.5 | 0.87 | 4.62 | 272 | NA | NA | NA | NA | Sepsis, lymphoma, diabetes mellitus, renal failure |
| 3 | M | 29 | ABCD | 1,300 | 4 | 2.21 | 5.00 | 234 | 1.63 | 126 | ++ | 290 | Sepsis, pneumonia, post-kidney transplant status, Kaposi's sarcoma |
| 4 | M | 68 | ABCD | 1,350 | 21.5 | 0.99 | 5.06 | 247 | 0.68 | 126 | ++ | 35 | Septic shock, pneumonia, hepatocellular carcinoma, renal failure |
| 5 | F | 46 | ABCD | 1,500 | 2 | 2.07 | 6.98 | 286 | 1.23 | 62 | + | 2 | Hodgkin's lymphoma, pneumonia |
| 6 | M | 44 | ABCD | 7,250 | 4 | 0.28 | 4.74 | 194 | 2.43 | 134 | + | 210 | Lymphoma, pneumonia |
| 7 | M | 53 | ABLC | 12,750 | 5 | 0.39 | 6.65 | 246 | 2.66 | 128 | + | 220 | Septic shock, pneumonia, lung cancer |
a
Two sets of samples (A and B) were obtained from patient 1; one sample set was obtained from each of the other patients. M, male; F, female; AMB LF, AMB lipid formulation; interval, duration between last dose and sampling time; crea, creatinine (normal range of concentrations in plasma, 0.70 to 1.20 mg/dl); normal range of protein concentrations in plasma, 6.30 to 8.20 g/dl; LDH, lactate dehydrogenase (normal range of concentrations in plasma, 100 to 250 U/liter); RBC, red blood cells (erythrocytes); ++, many; +, some; NA, not available.