TABLE 2.
Strain; description | Drug | Mutation frequency at:
|
||
---|---|---|---|---|
2× MIC | 4× MIC | 8× MIC | ||
SA510; MRSA, VRSA | CG400549 | ∼6.8 × 10−9 | ∼3.4 × 10−9 | ∼6.8 × 10−9 |
Vancomycin | NTa | NT | NT | |
Linezolid | <3.3 × 10−10 | <3.3 × 10−10 | <3.3 × 10−10 | |
Quinupristin-dalfopristin | ∼3.3 × 10−6 | ∼3.3 × 10−8 | <3.3 × 10−10 | |
Daptomycin | ∼2.6 × 10−7 | <2.6 × 10−10 | <2.6 × 10−10 | |
SA509; MRSA, VRSA | CG400549 | ∼3.0 × 10−7 | ∼1.5 × 10−8 | ∼1.5 × 10−8 |
Vancomycin | NT | NT | NT | |
Linezolid | <2.6 × 10−10 | <2.6 × 10−10 | <2.6 × 10−10 | |
Quinupristin-dalfopristin | ∼3.9 × 10−9 | <2.6 × 10−10 | <2.6 × 10−10 | |
Daptomycin | <1.7 × 10−10 | <1.7 × 10−10 | <1.7 × 10−10 | |
SA555; MRSA, VISA | CG400549 | ∼2.0 × 10−9 | <1.0 × 10−10 | <1.0 × 10−10 |
Vancomycin | <1.6 × 10−10 | <1.6 × 10−10 | <1.6 × 10−10 | |
Linezolid | ∼4 × 10−6 | <2 × 10−10 | <2 × 10−10 | |
Quinupristin-dalfopristin | <2 × 10−10 | <2 × 10−10 | <2 × 10−10 | |
Daptomycin | <2 × 10−10 | <2 × 10−10 | <2 × 10−10 | |
SA504; MRSA, VISA | CG400549 | <1.4 × 10−10 | <1.4 × 10−10 | <1.4 × 10−10 |
Vancomycin | <3.7 × 10−10 | <3.7 × 10−10 | <3.7 × 10−10 | |
Linezolid | <3.7 × 10−10 | <3.7 × 10−10 | <3.7 × 10−10 | |
Quinupristin-dalfopristin | <1.6 × 10−10 | <1.6 × 10−10 | <1.6 × 10−10 | |
Daptomycin | ∼4 × 10−6 | ∼2 × 10−8 | ∼3.6 × 10−9 | |
SA481; MRSA | CG400549 | ∼3.0 × 10−9 | ∼3.0 × 10−9 | ∼8.0 × 10−10 |
Vancomycin | <1.7 × 10−10 | <1.7 × 10−10 | <1.7 × 10−10 | |
Linezolid | ∼1.7 × 10−6 | <1.7 × 10−10 | <1.7 × 10−10 | |
Quinupristin-dalfopristin | <1.2 × 10−10 | <1.2 × 10−10 | <1.2 × 10−10 | |
Daptomycin | <1.9 × 10−10 | ∼4.7 × 10−8 | ∼3.9 × 10−9 | |
SA490; MRSA | CG400549 | ∼1.9 × 10−9 | ∼1.4 × 10−9 | <1.4 × 10−10 |
Vancomycin | <1.3 × 10−10 | <1.3 × 10−10 | <1.3 × 10−10 | |
Linezolid | <1.4 × 10−10 | <1.4 × 10−10 | <1.4 × 10−10 | |
Quinupristin-dalfopristin | ∼1.3 × 10−10 | <1.3 × 10−10 | <1.3 × 10−10 | |
Daptomycin | ∼7.6 × 10−8 | ∼2.6 × 10−8 | ∼6.4 × 10−9 | |
SA525; MRSA | CG400549 | ∼5.3 × 10−8 | ∼7.3 × 10−9 | ∼2.3 × 10−9 |
Vancomycin | <2.1 × 10−10 | ∼3.2 × 10−9 | <2.1 × 10−10 | |
Linezolid | ∼1.1 × 10−4 | <2.1 × 10−10 | <2.1 × 10−10 | |
Quinupristin-dalfopristin | ∼1.1 × 10−9 | <1.1 × 10−10 | <1.1 × 10−10 | |
Daptomycin | ∼2.7 × 10−8 | <1.3 × 10−10 | <1.3 × 10−10 | |
SA547; MRSA | CG400549 | ∼1.1 × 10−8 | ∼2.2 × 10−9 | ∼1.3 × 10−9 |
Vancomycin | <1.7 × 10−10 | <1.7 × 10−10 | <1.7 × 10−10 | |
Linezolid | ∼6.3 × 10−6 | <1.6 × 10−10 | <1.6 × 10−10 | |
Quinupristin-dalfopristin | ∼4.1 × 10−10 | <1.4 × 10−10 | <1.4 × 10−10 | |
Daptomycin | <1.9 × 10−10 | <1.9 × 10−10 | <1.9 × 10−10 | |
SA540; MSSA | CG400549 | ∼1.9 × 10−7 | ∼2.5 × 10−9 | ∼1.3 × 10−9 |
Vancomycin | <1.2 × 10−10 | <1.2 × 10−10 | <1.2 × 10−10 | |
Linezolid | <1.3 × 10−10 | <1.3 × 10−10 | <1.3 × 10−10 | |
Quinupristin-dalfopristin | ∼1.2 × 10−10 | ∼2.4 × 10−10 | <1.2 × 10−10 | |
Daptomycin | ∼1.2 × 10−6 | <1.2 × 10−10 | ∼4.9 × 10−9 | |
SA543; MSSA | CG400549 | ∼2.2 × 10−7 | ∼1.2 × 10−8 | ∼5.2 × 10−9 |
Vancomycin | ∼1.3 × 10−5 | ∼4.7 × 10−5 | ∼1.4 × 10−6 | |
Linezolid | <1.4 × 10−10 | <1.4 × 10−10 | <1.4 × 10−10 | |
Quinupristin-dalfopristin | <1.1 × 10−10 | <1.1 × 10−10 | <1.1 × 10−10 | |
Daptomycin | <2 × 10−10 | <2 × 10−10 | <2 × 10−10 |
NT, not tested.