TABLE 1.
Comparative cytotoxicities and anti-prion activities of cholesterol modulators and prion inhibitors in the 22L-N2a cell linea
| Cholesterol modulator | CC50 [μM] | PrPres EC50 [μM] | Prion inhibitor | CC50 [μM] | PrPres EC50 [μM] |
|---|---|---|---|---|---|
| EVE | >16 | 1.4 ± 0.8 | Quinacrine | 4.5 ± 1.3 | 1 ± 0.9 |
| PIO | 60.1 ± 11 | 40 ± 5.4 | Chlorpromazine | 83.4 ± 11.6 | 10 ± 3.9 |
| PG | 95.7 ± 18.6 | 35 ± 7.8 | Dextran sulfate 500 | >50 (μg/ml) | 0.2 (μg/ml) ± 0.1 |
| Verapamil | ≥100 | 15 ± 4.6 | Tannic acid | 6.6 ± 3.9 | 0.7 ± 0.3 |
| SaH | 68.4 ± 8.4 | 40 ± 6.4 | Amphotericin B | 28 ± 7 | 25 ± 5.7 |
| Cyclosporine A | 15.9 ± 4.6 | 10 ± 3.2 | Congo red | >10 | 0.6 ± 0.3 |
a
Values are the mean ± standard deviation of three or four independent experiments.