TABLE 1.
Species | Isolate code | Anidulafungin
|
Caspofungin
|
Micafungin
|
||||||
---|---|---|---|---|---|---|---|---|---|---|
RPMI MIC-2 (μg/ml) | 50% serum MIC-2 (μg/ml) | Ratioa | RPMI MIC-2 (μg/ml) | 50% serum MIC-2 (μg/ml) | Ratio | RPMI MIC-2 (μg/ml) | 50% serum MIC-2 (μg/ml) | Ratio | ||
C. albicans | 0012-025 | 0.0156 | 0.25 | 16 | 0.25 | 0.25 | 1 | 0.0156 | 1 | 64 |
0021-076 | 0.5 | 128 | 256 | 0.5 | 4 | 8 | 0.5 | 64 | 128 | |
C. glabrata | 0022-012 | 0.0313 | 1 | 32 | 0.5 | 0.5 | 1 | 0.0156 | 1 | 64 |
0049-038 | 0.0625 | 2 | 32 | 0.5 | 0.5 | 1 | 0.004 | 1 | 256 | |
C. krusei | 0001-058 | 0.0313 | 1 | 32 | 0.5 | 0.5 | 1 | 0.0625 | 2 | 32 |
0013-054 | 0.125 | 4 | 32 | 0.5 | 2 | 4 | 0.125 | 8 | 64 | |
ATCC 6258 | 0.125 | 2 | 16 | 0.5 | 4 | 8 | 0.0625 | 8 | 128 | |
C. lusitaniae | 0013-002 | 0.002 | 1 | 512 | 0.25 | 0.25 | 1 | 0.008 | 1 | 128 |
0015-049 | 0.125 | 1 | 8 | 0.5 | 1 | 2 | 0.0156 | 4 | 256 | |
C. parapsilosis | 0014-074 | 0.004 | 0.25 | 64 | 0.25 | 0.5 | 2 | 0.0156 | 0.5 | 32 |
0011-013 | 0.0313 | 2 | 64 | 0.25 | 1 | 4 | 0.0156 | 4 | 256 | |
0026-003 | 2 | 128 | 64 | 1 | 8 | 8 | 0.5 | 64 | 128 | |
0036-030 | 1 | 128 | 128 | 1 | 8 | 8 | 0.5 | 128 | 256 | |
ATCC 22019 | 0.5 | 64 | 128 | 0.5 | 8 | 16 | 0.5 | 32 | 64 | |
C. tropicalis | 0022-021 | 0.0156 | 2 | 128 | 0.5 | 0.5 | 1 | 0.0156 | 2 | 128 |
0050-028 | 1 | 128 | 128 | 0.5 | 2 | 4 | 0.25 | 32 | 128 | |
A. terreusb | 0031-087 | 0.0156 | 0.25 | 16 | 0.5 | 0.5 | 1 | 0.002 | 0.25 | 128 |
A. niger | 0001-073 | 0.001 | 0.5 | 512 | 0.0004 | 0.25 | 512 | 0.002 | 0.25 | 128 |
A. fumigatus | 0002-0016 | 2 | 128 | 64 | 8 | 128 | 16 | 0.0313 | 2 | 64 |
0020-018 | 0.5 | 128 | 256 | 16 | 128 | 8 | 0.0156 | 0.5 | 32 | |
0002-020 | 0.008 | 0.5 | 64 | 0.5 | 128 | 256 | 0.004 | 0.5 | 128 | |
0002-021 | 0.002 | 128 | 64,000 | 1 | 128 | 128 | 0.001 | 1 | 1,024 | |
A. flavus | 0001-033 | 4 | 128 | 32 | 32 | 128 | 4 | 0.125 | 128 | 1,024 |
0001-061 | 4 | 128 | 32 | 128 | 128 | 1 | 0.125 | 128 | 1,024 |
Shown is the ratio of the MIC-2 values with/without serum.
Growth rate was insufficient for A. terreus at 24 h; MIC-2 results were detected at 48 h.