TABLE 2.
Ratios of MIC-2 values with and without serum
| Genus | Time (h) | Drug | Ratio of MIC-2 in standard medium with/without 50% seruma
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | 64 | 128 | 256 | 512+ | |||
| Candida | 24 | Anidulafungin | 1 | 2 | 4 | 3 | 4 | 1 | 1 | ||||
| Caspofungin | 6 | 2 | 3 | 4 | 1 | ||||||||
| Micafungin | 2 | 4 | 6 | 4 | |||||||||
| 48 | Anidulafungin | 1 | 5 | 4 | 4 | 1 | 1 | ||||||
| Caspofungin | 3 | 2 | 3 | 6 | 2 | ||||||||
| Micafungin | 2 | 1 | 9 | 2 | 2 | ||||||||
| Aspergillus | 24 | Anidulafungin | 1 | 2 | 2 | 1 | 2 | ||||||
| Caspofungin | 2 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| Micafungin | 1 | 1 | 3 | 3 | |||||||||
| 48 | Anidulafungin | 2 | 4 | 2 | |||||||||
| Caspofungin | NA | ||||||||||||
| Micafungin | NA | ||||||||||||
a
NA, not applicable; for those drugs, most of the MIC-2 results with and without serum were out of range, and so ratio determinations were not meaningful.