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. 2006 Feb;127(2):145–158. doi: 10.1085/jgp.200509439

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Copyright © 2006, The Rockefeller University Press

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Figure 1. — Effects of DTT exposure on steady-state parameters of wt Na⁺/glucose cotransporter (wt SGLT1). (A) Effect of DTT on αMG cotransport current (I_cotr) of wt SGLT1. Estimation of the currents was done under control conditions (filled symbols) and in the presence of DTT (2.5 mM) (open symbols) on each oocyte (n = 3, paired experiments). (B) Effect of DTT on Na⁺ leak current (I_leak) of wt SGLT1. A 30-min exposure with 10 mM DTT was done before the experimental test of I_leak (done in the presence of DTT) (n = 6 for control conditions, filled symbols, n = 5 for DTT, open symbols, unpaired experiments). (C) Effect of DTT on apparent affinity for αMG (K_m ^α ^MG) as a function of membrane potential (V_m). Estimation of the apparent affinity for αMG was done under control conditions (filled symbols) and in the presence of DTT (2.5 mM) (open symbols) on each oocyte (n = 4, paired experiments).