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. 2006 Feb;127(2):145–158. doi: 10.1085/jgp.200509439

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Copyright © 2006, The Rockefeller University Press

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Figure 2. — Effect of DTT exposure on presteady-state parameters of wt Na⁺/glucose cotransporter (wt SGLT1). (A) Presteady-state currents (Pz-sensitive currents in the absence of glucose) of a typical oocyte expressing wt SGLT1 under control conditions and after exposure to DTT (30 min preincubation with 10 mM DTT, with DTT present in subsequent experimental solutions). (B) Effect of DTT on transferred charges (Q-V curve) of wt SGLT1. Q-V curves were fitted with a Boltzmann equation (see MATERIALS AND METHODS), adjusted to 0 at hyperpolarizing voltages and normalized with respect to the extrapolated Q_max (n = 9 for control conditions, filled symbols, n = 6 for DTT, open symbols, unpaired experiments). (C) Time constant of the 10-ms component of presteady-state currents of wt SGLT1 compared with wt + DTT. The curves represent the time constants evaluated with a four-state model of presteady-state currents with parameters described in Table I.