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. 2006 Feb;127(2):171–182. doi: 10.1085/jgp.200509456

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Copyright © 2006, The Rockefeller University Press

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Figure 7. — A proposed hypothetical model of the mini-dystrophin reduction effect on PLC activity. (A) During depolarization, the activation of DHPRs, followed by calcium release from RYRs (described as fast) would also stimulate PLC through Gi protein (Araya et al., 2003). The IP3, produced from the PLC activity, reaches IP3Rs from the SR and leads to calcium release (slow). (B) The presence of the mini-dystrophin protein would repress the activity of PLC via the Gi protein and consequently reduce the slow release from IP3 receptors.