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. 2006 Mar;127(3):329–340. doi: 10.1085/jgp.200509402

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Copyright © 2006, The Rockefeller University Press

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Figure 3. — Neomycin slows down both activation and deactivation of macroscopic SV currents. (A) Time required for current half activation is plotted against the applied membrane potential. Data points represent mean values (± SEM) determined in control conditions (open circles; n = 9), in the presence of 10 μM (closed squares; n = 5) and 50 μM neomycin (open squares; n = 4). Lines are best fits to a monoexponential function. The increase of activation time saturated already at 10 μM neomycin; consequently, values for 200 μM are not given for clarity, but were comparable and overimpose to 10 and 50 μM. (B) Time constants of current deactivation τ are plotted against the tail potential. Data points represent mean values (± SEM) of τ determined in control conditions (open circles; n = 9) and in the presence of 10 μM (closed squares; n = 5), 200 μM (closed triangles; n = 4), and 1 mM neomycin (closed diamonds; n = 3). Lines are best fits to a monoexponential function.