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. 2006 Mar;127(3):277–289. doi: 10.1085/jgp.200509399

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Copyright © 2006, The Rockefeller University Press

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Figure 1. — Time-dependent block induced by β4_154–167 at 50 mV. Current traces of hNav1.5-CW mutant channels were recorded after the pipette break-in under the whole-cell configuration. The pipette solution contained 125 μM β4_154–167. (A) Currents became larger during initial dialysis but exhibited little or no fast inactivation. Traces were recorded at the times labeled. (B) The time-dependent block was progressively developed during continued dialysis and reached steady state around 15–30 minutes. (C) The time-dependent block was well fitted by a single exponential function with a τ value of 0.86 ms (dashed line). Holding potential was set at −140 mV.