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. 2006 Mar;127(3):277–289. doi: 10.1085/jgp.200509399

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Copyright © 2006, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 12. — A β4_154–167-resistant phenotype in hNav1.5-CW/F1760K mutant Na⁺ channels. Traces of hNav1.5-CW/F1760K mutant Na⁺ currents at 50 mV were recorded after >30 min under whole-cell configuration in the absence (A) or presence (B) of 1 mM β4_154–167 within the pipette solution. The τ values for the tail current decay were measured at 190.6 ± 30.0 μs and 219.7 ± 19.6 μs (n = 5) without and with 1 mM β4_154–167, respectively. The difference in τ values is not statistically significant (P = 0.44). The maintained currents at the end of the test pulse in A and B were measured, normalized with the peak current amplitude, and plotted in C (n = 5). No statistical difference was found in these measurements. Error bars represent SD.