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. 2006 Mar;127(3):277–289. doi: 10.1085/jgp.200509399

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Copyright © 2006, The Rockefeller University Press

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Figure 3. — Time-dependent block at various voltages. Families of superimposed hNav1.5-CW current traces were recorded at various voltages in the absence (A) and presence (B) of 125 μM β4_154–167. Traces corresponding to −70 and 50 mV are labeled. For the steady-state block of β4_154–167, a slower time frame was used in B, which was recorded ∼30 min after the pipette break-in. (C) The decaying phase of the current traces at 1 mM β4_154–167 was fitted by a single exponential function with a time constant, τ. The τ value was inverted and plotted against the corresponding voltage (n = 6 except at −10 mV, where n = 3). Error bars represent SEM.