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. 2006 Mar;127(3):267–276. doi: 10.1085/jgp.200509409

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Copyright © 2006, The Rockefeller University Press

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Figure 1. — PcTx1 did not strongly inhibit ASIC1b. (A) ASIC1b currents were repeatedly activated by pH 5.0 for 10 s. Even 500 nM PcTx1 did not inhibit the current, when it was applied at pH 7.1 (n = 5). When applied at pH 6.9, 100 nM PcTx1 slightly inhibited the current (n = 6). (B) H⁺ dependence of steady-state desensitization of ASIC1b currents in the absence (n = 6, open circles) or presence (n = 6, filled circles) of 100 nM PcTx1. PcTx1 was applied for 120 s in the conditioning period; available channels were assessed with pH 5.0. Solid lines are fits of the mean values of each data point to a Hill function (Eq. 1). PcTx1 slightly but significantly (P = 0.04) shifted the steady-state desensitization curve of ASIC1b leftwards.