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. 2006 Mar;127(3):267–276. doi: 10.1085/jgp.200509409

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Copyright © 2006, The Rockefeller University Press

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Figure 5. — PcTx1 significantly prolonged the desensitization of ASIC1 currents. 500 nM PcTx1 slightly but significantly (P < 0.01, n = 5) slowed down desensitization of ASIC1a currents. Desensitization of ASIC1b currents was more strongly slowed down (P ≪ 0.01, n = 6). Conditioning pH was pH 7.9 for ASIC1a and pH 8.0 for ASIC1b, respectively. Acidic test pH was always pH 5.0. Top, examples of current traces. Scaled overlaid traces before and after PcTx1 application are shown for better comparison. Bottom, bars representing desensitization time constants of ASIC1 currents before and after PcTx1 application.