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. 2006 Jun;127(6):719–735. doi: 10.1085/jgp.200509438

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Copyright © 2006, The Rockefeller University Press

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Figure 1. — Thermodynamic cycles and AChR function. An MWC-type of kinetic scheme (Monod et al., 1965) applied to the particular case of the (muscle) AChR. C, O, and D denote the closed, open, and desensitized conformations of the channel, respectively. In this paper, we refer to the two types of nonconductive conformations (closed and desensitized), collectively, as shut states. A denotes an agonist molecule that can bind to the neurotransmitter binding sites. The broken arrows indicate the uncertainty as to the extent to which recovery from desensitization of mono- and unliganded AChRs proceeds directly (Desensitized→Closed) or through an open-channel conformation (Desensitized→Open→Closed). The cycle considered for arriving at Eq. 1 is displayed in bold.