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. 2006 Jun;127(6):719–735. doi: 10.1085/jgp.200509438

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Copyright © 2006, The Rockefeller University Press

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Figure 5. — Wild-type AChR single-channel inward currents elicited by various concentrations of ACh (A) or choline (B). Membrane potential ≅ −100 mV. Display f _c ≅ 4 kHz. Openings are downward deflections. With the exception of the 200 μM and 2 mM choline traces (which are arbitrarily chosen sections of data), all stretches of currents are example clusters of single-channel openings identified as elaborated in Materials and Methods. In the presence of choline alone, clusters of openings could be identified only at [choline] ≥ 14 mM. For display purposes only, the durations of plotted clusters are similar, but these do not reflect the mean cluster duration under each agonist condition. At the concentrations studied here, fast open-channel block by ACh is manifest as a concentration-dependent increase in the proportion of brief shuttings. Fast open-channel block by choline is manifest as a concentration-dependent decrease in the (apparent) single-channel current amplitude and as a prolongation of the (apparent) open times (Purohit and Grosman, 2006). Note the different time scales in A and B.