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. 2006 Jun;127(6):611–622. doi: 10.1085/jgp.200609519

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Copyright © 2006, The Rockefeller University Press

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Figure 4. — Basal PKCβ and PKCɛ activity is not required for Ca²⁺ sparklet activity in arterial smooth muscle. (A) Time course of [Ca²⁺]_i in a Ca²⁺ sparklet site before and after the application of 10 μM nifedipine. (B) Time course of [Ca²⁺]_i in a Ca²⁺ sparklet under control conditions and after perfusion of a solution without Ca²⁺. Time course of [Ca²⁺]_i in a Ca²⁺ sparklet site before and after the application of (C) 100 nM Gö6976 or (D) 50 nM PKCβi. (E) Bar plot of the mean ± SEM nP_s under control conditions and after application of Gö6976 or PKCβi. *, significantly different from control.