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. 2006 Jun;127(6):659–672. doi: 10.1085/jgp.200609504

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Copyright © 2006, The Rockefeller University Press

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Figure 7. — Zinc catalysis theory. A standard method of measuring production is to assay the reduction of cytochrome c. It was proposed recently (Ahluwalia et al., 2004) that metals like Zn²⁺ or Cd²⁺ may rapidly convert to H₂O₂ such that the observed cytochrome c reduction would be attenuated. If this were the case, then the H₂O₂ production rate would be unaffected by Zn²⁺. The data in Fig. 8 (Amplex red assay) disprove this theory.

Inline graphic — Zinc catalysis theory. A standard method of measuring production is to assay the reduction of cytochrome c. It was proposed recently (Ahluwalia et al., 2004) that metals like Zn²⁺ or Cd²⁺ may rapidly convert to H₂O₂ such that the observed cytochrome c reduction would be attenuated. If this were the case, then the H₂O₂ production rate would be unaffected by Zn²⁺. The data in Fig. 8 (Amplex red assay) disprove this theory.