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. 2006 Jul;128(1):103–118. doi: 10.1085/jgp.200609505

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Copyright © 2006, The Rockefeller University Press

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Figure 11. — Proposal for an extended Post-Albers pump cycle of the Na,K-ATPase induced by the effect PTX. Due to the weak ion selectivity of the PTX-modified ion pump, the ions bound can be Na⁺, K⁺, and H⁺. Therefore, “X” denotes that different ions are transported under appropriate buffer composition from the extracellular side to the cytoplasm. (In the case of H⁺, the indicated exchange of two X⁺ against two H⁺ in the E₁ state is unnecessary.) The underlined states, and , represent the channel-like states of the Na,K-ATPase. The missing left parenthesis in the state shall indicate that the cytoplasmic gate of the Na,K-ATPase is still held in its open position.

Inline graphic — Proposal for an extended Post-Albers pump cycle of the Na,K-ATPase induced by the effect PTX. Due to the weak ion selectivity of the PTX-modified ion pump, the ions bound can be Na⁺, K⁺, and H⁺. Therefore, “X” denotes that different ions are transported under appropriate buffer composition from the extracellular side to the cytoplasm. (In the case of H⁺, the indicated exchange of two X⁺ against two H⁺ in the E₁ state is unnecessary.) The underlined states, and , represent the channel-like states of the Na,K-ATPase. The missing left parenthesis in the state shall indicate that the cytoplasmic gate of the Na,K-ATPase is still held in its open position.