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. 2006 Jul;128(1):133–145. doi: 10.1085/jgp.200609498

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Copyright © 2006, The Rockefeller University Press

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Figure 2. — Activation of mKv1.7 channels. Representative outward currents in response to 500-ms depolarizing test potentials ranging from −60 to +80 mV in 10-mV increments, extracellular solution NFR, V_h= −100 mV. mKv1.7L is shown in black (A) and mKv1.7S in gray (B). (C) Steady-state activation curves for mKv1.7L (n = 20, black) and mKv1.7S (n = 15, gray). Mean ± SEM of the relative conductances are plotted against the potential. The smooth line corresponds to Boltzmann fits to the data. (D) Rise time plot of mKv1.7L (n = 13) and mKv1.7S (n = 20) currents measured as the time in ms required for reaching 75% of I_max (RT₇₅) from on-cell patch clamp experiments. mKv1.7L data are shown in black and mKv1.7S in gray. The inset in D presents superimposed early current traces of on-cell patch clamp recordings of mKv1.7L and mKv1.7S channels.