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. 2006 Jul;128(1):133–145. doi: 10.1085/jgp.200609498

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Copyright © 2006, The Rockefeller University Press

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Figure 6. — N-terminal determinants of mKv1.7 channels redox sensitivity. (A) Scaled and superimposed current traces of the different N terminus mutants (+40 mV, 500 ms, V_h = −100 mV) of Kv1.7L. Black traces correspond to recordings under control conditions (NFR) and red traces are currents recorded in the presence of 300 μM DTDP. The dashed lines correspond to 0 current. Mutations are indicated in each panel. (B) Relative change in the inactivation time constant upon oxidation of mKv1.7 mutant channels. Time constants obtained from monoexponential fits to the current decay upon +40 mV pulses under control conditions (τ_control) divided by inactivation time constant under DTDP oxidizing conditions (τ_oxidized) (mean ± SEM; n = 5–15).