Table I.
Characteristics of the Currents Mediated by mKv1.7L and mKv1.7S Channels Expressed in Xenopus Oocytes Determined by TEVC Measurements
V1/2 | Slope | RT75 | τInac | V1/2Inac | SlopeInac | τRec1 | τRec2 | τCI
2.5 mM K+ |
τCI
117.5 mM K+ |
|
---|---|---|---|---|---|---|---|---|---|---|
mV | ms | ms | mV | mV | ms | s | s | s | ||
mKv1.7L | 4.4 ± 1.4 | 15.4 ± 0.5 | 4.4 ± 0.5 | 181.8 ± 15.4 | −40 ± 0.7 mV | 4 ± 0.3 | 1.2 ± 0.1 | 45.3 ± 4.5 | 8.1 ± 0.3 | 22.5 ± 4.4 |
n = 20 | n = 20 | n = 12 | n = 15 | n = 5 | n = 5 | n = 15 | n = 15 | n = 20 | n = 23 | |
mKv1.7S | −4.3 ± 2.9 | 13.3 ± 0.6 | 7.5 ± 0.7 | 643.2 ± 80.1 | −21 ± 2 mV | 7 ± 0.7 | 0.8 ± 0.1 | 34.6 ± 1.9 | 14.1 ± 4.8 | 38 ± 14.6 |
n = 15 | n = 15 | n = 12 | n = 13 | n = 5 | n = 5 | n = 9 | n = 9 | n = 6 | n = 5 | |
** | ns | ** | *** | *** | ** | ** | ns | ** | ** |
RT75 and τInac are at + 40 mV. τRec1 and τRec2 are the time constants for the recovery from inactivation. ns, not significant. *, P < 0.01; **, P < 0.001; ***, P = 0.0001.