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. 2006 Jul;128(1):55–71. doi: 10.1085/jgp.200609500

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Copyright © 2006, The Rockefeller University Press

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Figure 5. — Time course of recovery from inactivation of the hERG Na⁺ current. (A) Voltage protocol and the Na⁺ currents for studying recovery from inactivation. From a holding potential of −80 mV, the cell was depolarized to 70 mV for 6 s until steady-state inactivation was reached. The cell was then clamped to −80 mV for different periods of time before it was depolarized to 70 mV for 800 ms to observe channel recovery. The interpulse interval was 120 s. (B) Time-dependent recovery of the Na⁺ current. The superimposed line represents the best fit of the averaged data from 13 cells to double exponential functions.