Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2006 Oct;128(4):423–441. doi: 10.1085/jgp.200609521

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2006, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 3. — Steady-state block of BK channels by EBP is dominated by long block events. (A) Macroscopic BK currents were recorded before (control) and after the application of 3 μM EBP. Voltage protocol is shown above the traces. Currents were not leak subtracted nor averaged in order to demonstrate the unaltered single channel openings. The segment of current enclosed in the dotted box was amplified both vertically and horizontally to visualize single channel currents. (B) Single channel recordings of BK currents in the absence (control) and presence of 0.3 μM EBP at 80 mV. Records were digitally filtered at 1 kHz. Dashed lines in this and other single channel records indicate open and shut levels, as marked by “o” and “s.” In the presence of blockers, open and shut levels are determined based on the current amplitude in control records. When channel closure is rare, occasional long shut segments are deliberately included in single channel records in order to show the shut levels.